NSC 3852

Name: NSC 3852
Brand: Tocris Bioscience
SKU: 2521

Catalog #: 2521 Datasheet / COA / SDS

Discontinued Product

2521 has been discontinued.

View all Class II Histone Deacetylases Inhibitors products.

NSC 3852 | CAS No. 3565-26-2 | Class II Histone Deacetylases Inhibitors

1 Image

Description: Histone deacetylase inhibitor

Chemical Name: 5-Nitroso-8-quinolinol

View All Products for Class II Histone Deacetylases Inhibitors

Product Details

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

NSC 3852 is a histone deacetylase inhibitor. Causes cell differentiation and antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo. Also exhibits antiproliferative, proapoptotic and differentiation effects in pediatric acute myeloid leukemia cell lines.

Technical Data

M.Wt:

174.16

Formula:

C₉H₆N₂O₂

Solubility:

Soluble to 100 mM in DMSO and to 10 mM in ethanol

Storage:

Store at RT

CAS No:

3565-26-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model.
Martirosyan et al.
Biochem.Pharmacol., 2004;68:1729
Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells.
Martirosyan et al.
J.Pharmacol.Exp.Ther., 2006;317:546
Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia.
Wiggers et al.
Pediatr.Blood Cancer., 2019;

Product Datasheets

COA view current batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for NSC 3852

There are currently no reviews for this product. Be the first to review NSC 3852 and earn rewards!

Have you used NSC 3852?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.