Chemical Name: 3,5-Bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propene-1-yl)-4-piperidone
Biological ActivityInhibitor of 19S regulatory particle associated deubiquitinating enzymes (DUBs), UCHL5 and USP14. Shows minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP, BAP1 and proteasome activity. Induces apoptosis by cathepsin D-dependent caspase-cleavage (IC50 = 0.5 μM). Displays antitumor activity in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system.
Berndtsson et al.
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
D'Arcy et al.
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