Inhibitor of 19S regulatory particle associated deubiquitinating enzymes (DUBs), UCHL5 and USP14. Shows minimal inhibition of UCHL-1, UCHL-3, USP2, USP7, USP, BAP1 and proteasome activity. Induces apoptosis by cathepsin D-dependent caspase-cleavage (IC50
= 0.5 μ
M). Displays antitumor activity in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system.
Berndtsson et al.
Inhibition of proteasome deubiquitinating activity as a new cancer therapy.
D'Arcy et al.