Catalog Number: 2203
Alternate Names: N-Palmitoyldopamine
Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]hexadecanamide
Biological Activity
Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA; lowers EC50 from ~ 90 to ~ 30 nM.
Technical Data
  • M.Wt:
    391.59
  • Formula:
    C24H41NO3
  • Solubility:
    Soluble to 5 mM in ethanol with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    136181-87-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. N-Oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia.
    Chu et al.
    J.Biol.Chem., 2003;278:13633
  2. Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels.
    De Petrocellis et al.
    Br.J.Pharmacol., 2004;143:251

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