PALDA
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Description: Endogenous lipid; potentiates effects of endovanilloids at TRPV1 receptors
Alternative Names: N-Palmitoyldopamine
Chemical Name: N-[2-(3,4-Dihydroxyphenyl)ethyl]hexadecanamide
Purity: ≥98%
Biological Activity
Endogenous fatty acid dopamide that displays 'entourage' effects on endovanilloids NADA and anandamide. Inactive at TRPV1 and CB1 receptors (at concentrations up to 5 μM) and does not inhibit AMT or FAAH (IC50 > 25 μM). However, potentiates TRPV1-mediated effects of NADA; lowers EC50 from ~ 90 to ~ 30 nM.Technical Data
M.Wt:
391.59
Formula:
C24H41NO3
Solubility:
Soluble to 5 mM in ethanol with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
136181-87-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
N-OleoylDA, a novel endogenous capsaicin-like lipid that produces hyperalgesia.
Chu et al.
J.Biol.Chem., 2003;278:13633 -
Actions of two naturally occurring saturated N-acylDAs on transient receptor potential vanilloid 1 (TRPV1) channels.
De Petrocellis et al.
Br.J.Pharmacol., 2004;143:251
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