Reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (Ki
= 3.4 μ
M). Inhibits the basal ATPase activity of MKLP-2 (IC50
= 1.35 μ
M). Exhibits selectivity for MKLP-2 over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Cell permeable.
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All Tocris products are intended for laboratory research use only.
Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor.
Tcherniuk et al.
Agnew Chem.Int.Ed.Engl., 2010;49:8228