Chemical Name: (Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
Biological ActivityReversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (Ki = 3.4 μM). Inhibits the basal ATPase activity of MKLP-2 (IC50 = 1.35 μM). Exhibits selectivity for MKLP-2 over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Cell permeable.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Relocation of Aurora B and survivin from centromeres to the central spindle impaired by a kinesin-specific MKLP-2 inhibitor.
Tcherniuk et al.
Agnew Chem.Int.Ed.Engl., 2010;49:8228
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for Paprotrain
There are currently no reviews for this product. Be the first to review Paprotrain and earn rewards!
Have you used Paprotrain?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image