Catalog # Availability Size / Price Qty
Paprotrain | CAS No. 57046-73-8 | Kinesin Inhibitors
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Description: Reversible inhibitor of MKLP-2

Chemical Name: (Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile

Product Details

Biological Activity

Reversible, non-ATP competitive inhibitor of mitotic kinesin-like protein 2 (MKLP-2) (Ki = 3.4 μM). Inhibits the basal ATPase activity of MKLP-2 (IC50 = 1.35 μM). Exhibits selectivity for MKLP-2 over 12 other members of the kinesin superfamily, including the closely-related MKLP-1. Cell permeable.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in ethanol
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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