PBP 10

Name: PBP 10
Brand: Tocris Bioscience
SKU: 4611

Tocris Bioscience | Catalog # 4611

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Citations (9)

Product Documents

Selective FPR2 antagonist; cell permeable

Discontinued Product

4611 has been discontinued. View all Formyl Peptide Receptor Antagonists products.

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Selective FPR2 antagonist; cell permeable

View all Formyl Peptide Receptor Antagonists »

Product Description

PBP 10 is a selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP₂ binding activity in vitro and blocks cell motility. Also exhibits antiviral activity against influenza viruses via inhibition of viral-induced ERK activation.

Product Specifications for PBP 10

Molecular Weight

1712.10

Formula

C₈₄H₁₂₆N₂₄O₁₅

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

794466-43-6

PubChem ID

16143872

InChI Key

OIOWMSSANHIUTR-NVWDZAHRSA-N

SMILES

CCN(CC)C1=CC2=C(C=C1)C(C1=CC=CC=C1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC([NH-])=N)C(O)=O)=C1C=CC(C=C1O2)=[N+](CC)CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 9 publications citing the usage of this product.

Forsman Structural characterization and inhibitory profile of formyl peptide receptor 2 selective peptides descending from a PIP2-binding domain of gelsolin. J.Immunol. 2012 PMID: 22706076
Courtin Antiviral activity of formyl peptide receptor 2 antagonists against influenza viruses. Antiviral.Res. 2017 PMID: 28483551
Cunningham Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly. J.Biol.Chem. 2011 PMID: 11533030

Product Documents for PBP 10

Certificate of Analysis

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Product Specific Notices for PBP 10

For research use only

Citations for PBP 10

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