Selective formyl peptide receptor 2 (FPR2) antagonist; cell permeable. Selectively inhibits FPR2-mediated NADPH oxidase activity but has no effect on FPR1 signaling in neutrophils. Displays PIP2
binding activity in vitro
and blocks cell motility.
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Cell permeant polyphosphoinositide-binding peptides that block cell motility and actin assembly.
Cunningham et al.
Structural characterization and inhibitory profile of formyl peptide receptor 2 selective peptides descending from a PIP2-binding domain of gelsolin.
Forsman et al.