Catalog Number: 4086
Chemical Name: 4-[[[7-(Diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid 2-(1,2,3,4-tetrahydro-9-acridinyl)hydrazide
Biological Activity
Potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50 values are 280 pM and 16 nM respectively). Targets and labels β-amyloid plaques in histochemical analysis.
Technical Data
  • M.Wt:
    589.68
  • Formula:
    C35H35N5O4
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at +4°C
  • CAS No:
    1192750-33-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles.
    Kacza et al.
    Eur.J.Neurosci., 2010;31:99
  2. A gorge-spanning, high-affinity cholinesterase inhibitor to explore β-amyloid plaques.
    Elsinghorst et al.
    Org.Biomol.Chem., 2009;7:3940
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PE 154 include:

1 Citations: Showing 1 - 1

  1. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
    Authors: Zemkova Et al.
    Endocrinology 2011;152:3842

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