Chemical Name: 4-[[[7-(Diethylamino)-2,4-dioxo-2H-1-benzopyran-3(4H)-ylidene]methyl]amino]-benzeneacetic acid 2-(1,2,3,4-tetrahydro-9-acridinyl)hydrazide
Biological ActivityPotent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC50 values are 280 pM and 16 nM respectively). Targets and labels β-amyloid plaques in histochemical analysis.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles.
Kacza et al.
A gorge-spanning, high-affinity cholinesterase inhibitor to explore β-amyloid plaques.
Elsinghorst et al.
Citation for PE 154
The citations listed below are publications that use Tocris products. Selected citations for PE 154 include:
1 Citation: Showing 1 - 1
NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
Authors: Zemkova Et al.
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