Inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluR2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluR2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).
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Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.
Kim et al.
AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses.
Li et al.
NSF ATPase and α-/β-SNAPs disassemble the AMPA receptor-PICK1 complex.
Hanley et al.
PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.
Daw et al.