pep2-AVKI

Name: pep2-AVKI
Brand: Tocris Bioscience
SKU: 1600

Tocris Bioscience | Catalog # 1600

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Product Documents

Peptide inhibitor of GluA2 subunit binding to PICK1

Discontinued Product

1600 has been discontinued. View all AMPA Receptor Inhibitors products.

Technical Data
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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Peptide inhibitor of GluA2 subunit binding to PICK1

View all AMPA Receptor Inhibitors »

Product Description

pep2-AVKI is an inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluA2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).

Product Specifications for pep2-AVKI

Molecular Weight

1268.47

Formula

C₆₀H₉₃N₁₃O₁₇

Storage

Desiccate at -20°C

CAS Number

1315378-69-8

PubChem ID

90479810

InChI Key

SODUKHPKIVEQLX-OCXIBOJYSA-N

SMILES

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 2mg/ml in water

Calculators

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Background References

References are publications that support the biological activity of the product.

Li AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nat.Neurosci. 1999 PMID: 10526335
Hanley NSF ATPase and α-/β-SNAPs disassemble the AMPA receptor-PICK1 complex. Neuron 2002 PMID: 11931741
Kim Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression. Proc.Natl.Acad.Sci.U.S.A. 2001 PMID: 11573007
Daw PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses. Neuron 2000 PMID: 11163273

Product Documents for pep2-AVKI

Certificate of Analysis

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Product Specific Notices for pep2-AVKI

For research use only

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