Catalog Number: 1600
Biological Activity
Inhibitor peptide that selectively disrupts binding of the AMPA receptor subunit GluR2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Does not affect binding of GluR2 to GRIP or ABP and does not increase AMPA current amplitude or affect long term depression (LTD).
Technical Data
  • M.Wt:
    1268.47
  • Formula:
    C60H93N13O17
  • Sequence:
    YNVYGIEAVKI
  • Solubility:
    Soluble to 2 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    1315378-69-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Interaction of the AMPA receptor subunit GluR2/3 with PDZ domains regulates hippocampal long-term depression.
    Kim et al.
    Proc.Natl.Acad.Sci.U.S.A., 2001;98:11725
  2. AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses.
    Li et al.
    Nat.Neurosci., 1999;2:972
  3. NSF ATPase and α-/β-SNAPs disassemble the AMPA receptor-PICK1 complex.
    Hanley et al.
    Neuron, 2002;34:53
  4. PDZ proteins interacting with C-terminal GluR2/3 are involved in a PKC-dependent regulation of AMPA receptors at hippocampal synapses.
    Daw et al.
    Neuron, 2000;28:873

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