Catalog Number: 4302
Chemical Name: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-(Ethoxycarbonyl)butyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic acid tert-butylamine salt
Biological Activity
Angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.05 nM). Brain penetrant. Suppresses the increase in hippocampal ACE activity and improves cognition in PS2APP-transgenic mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Angiotensin-converting enzyme (ACE) inhibitors have different selectivity for bradykinin binding sites of human somatic ACE.
    Ceconi et al.
    Eur.J.Pharmacol., 2007;577:1
  2. Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors.
    Takai et al.
    Hypertens.Res., 2004;27:213
  3. Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease.
    Dong et al.
    FASEB J., 2011;25:2911
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