PF 06650833

Tocris Bioscience | Catalog # 6373

Potent and selective IRAK4 inhibitor
Tocris Bioscience
Discontinued Product
6373 has been discontinued. View all IRAK Inhibitors products.

Key Product Details

Description

Potent and selective IRAK4 inhibitor
View all IRAK Inhibitors »

Product Description

PF 06650833 is a potent and selective IRAK4 inhibitor (IC50 = 2 nM). Inhibits LPS-induced TNF-α secretion in vivo. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for PF 06650833

Molecular Weight

361.37

Formula

C18H20FN3O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

1-[[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-6-isoquinolinecarboxamide

CAS Number

1817626-54-2

PubChem ID

118414016

InChI Key

JKDGKIBAOAFRPJ-ZBINZKHDSA-N

SMILES

CC[C@H]1[C@H](NC([C@H]1F)=O)COC2=NC=CC3=C2C=C(C(C(N)=O)=C3)OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.14 100

Preparing Stock Solutions for PF 06650833

The following data is based on the product molecular weight 361.37.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.84 mL 27.67 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 6 publications citing the usage of this product.

Product Documents for PF 06650833

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PF 06650833

For research use only

Customer Reviews for PF 06650833 (1)

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  • Works well for kinase assay
    Name: Scott Scarneo
    Species: Human
    Assay Type: In Vitro
    Verified Customer | Posted 02/06/2019
    Easy to use and store. I used this assay for a kinase assay against TAK1 in vitro of purified TAK-TAB1.
    PF 06650833 6373

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