Chemical Name: 1-[[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxo-2-pyrrolidinyl]methoxy]-7-methoxy-6-isoquinolinecarboxamide
Biological ActivityPF 06650833 is a potent and selective IRAK4 inhibitor (IC50 = 2 nM). Inhibits LPS-induced TNF-α secretion in vivo. Orally bioavailable.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
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Easy to use and store. I used this assay for a kinase assay against TAK1 in vitro of purified TAK-TAB1.