PF 9184

Catalog # Availability Size / Price Qty
5917/10
5917/50
Cat.No. 5917 - PF 9184 | C21H14Cl2N2O4S | CAS No. 1221971-47-6
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Description: Potent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor

Chemical Name: N-[3',4'-Dichloro(1,1'-biphenyl)-yl]-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

Purity: ≥98%

Product Details
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Biological Activity

Potent microsomal prostaglandin E synthase 1 (mPGES-1) inhibitor (IC50 values are 16.5 and 1080 nM for human and rat mPGES-1, respectively). Exhibits >6500-fold selectivity for mPGES-1 over COX-1 and COX-2. Inhibits IL-1β-induced PGE2 synthesis in vitro.

Technical Data

M.Wt:
461.32
Formula:
C21H14Cl2N2O4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1221971-47-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

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