PHPS1 sodium salt

Key Product Details

Product Description

PHPS1 sodium salt is a Shp2 (PTPN11) inhibitor (IC₅₀ = 2.1 μM). Inhibits hepatocyte growth factor-stimulated epithelial cell scattering and branching morphogenesis in vitro. Increases myelin basic protein (MBP) levels in zebrafish embryo spinal cord. Also ameliorates bleomycin-induced pulmonary and dermal fibrosis in vivo.

Product Specifications for PHPS1 sodium salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PHPS1 sodium salt

The following data is based on the product molecular weight 487.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.26 mL	51.29 mL	102.58 mL
1 mM	2.05 mL	10.26 mL	20.52 mL
2 mM	1.03 mL	5.13 mL	10.26 mL
10 mM	0.21 mL	1.03 mL	2.05 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Ahrendsen The protein tyrosine phosphatase Shp2 regulates oligodendrocyte differentiation and early myelination and contributes to timely remyelination. J.Neurosci. 2018 PMID: 29217681
• Zehender The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis. Nat.Commun. 2018 PMID: 30108215
• Hellmuth Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. Proc.Natl.Acad.Sci.U.S.A 2008 PMID: 18480264

Product Documents for PHPS1 sodium salt