PHPS1 sodium salt

Catalog # Availability Size / Price Qty
6771/5
6771/25
PHPS1 sodium salt | Protein Tyrosine Phosphatase Inhibitors
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Description: Shp2 (PTPN11) inhibitor

Chemical Name: 4-[2-[1,5-Dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]benzenesulfonic acid sodium salt

Purity: ≥98%

Product Details
Reviews

Biological Activity

Shp2 (PTPN11) inhibitor (IC50 = 2.1 μM). Inhibits hepatocyte growth factor-stimulated epithelial cell scattering and branching morphogenesis in vitro. Increases myelin basic protein (MBP) levels in zebrafish embryo spinal cord. Also ameliorates bleomycin-induced pulmonary and dermal fibrosis in vivo.

Technical Data

M.Wt:
487.42
Formula:
C21H14N5O6SNa
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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