Chemical Name: N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazoly]acetamide
Biological ActivityPotent PI 3-Kγ, PI 3-Kα and PI 4-KIIIβ inhibitor (IC50 values are 16, 39 and 19 nM, respectively). Rescues PI 3K inhibition of growth of S. cerevisiae in a reverse halo assay.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Structures of PI4KIIIβ complexes show simultaneous recruitment of Rab1 1 and its effectors.
Burke et al.
Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 α.
Zunder et al.
Cancer Cell, 2008;14:180
A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling.
Knight et al.
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