PKC 412

Tocris Bioscience | Catalog # 2992

Protein kinase C inhibitor
Tocris Bioscience
Discontinued Product
2992 has been discontinued. View all Protein Kinase C Inhibitors products.

Key Product Details

Description

Protein kinase C inhibitor

Alternative Names

CGP 41251
View all Protein Kinase C Inhibitors »

Product Description

PKC 412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1, EGFR and MARK (microtubule affinity regulating kinase). Displays potent antitumor activity. Identified as targeting human host cell proteins that interact with SARS-CoV-2.

Product Specifications for PKC 412

Molecular Weight

570.64

Formula

C35H30N4O4

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

[9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide

CAS Number

120685-11-2

PubChem ID

9829523

InChI Key

BMGQWWVMWDBQGC-IIFHNQTCSA-N

SMILES

O=C(NC6)C1=C6C4=C3C2=C1C8=C(C=CC=C8)N2[C@](C[C@@H](N(C(C9=CC=CC=C9)=O)C)[C@H]7OC)([H])O[C@]7(C)N3C5=CC=CC=C45

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 8.56 15

Preparing Stock Solutions for PKC 412

The following data is based on the product molecular weight 570.64.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.15 mM 11.68 mL 58.41 mL 116.83 mL
0.75 mM 2.34 mL 11.68 mL 23.37 mL
1.5 mM 1.17 mL 5.84 mL 11.68 mL
7.5 mM 0.23 mL 1.17 mL 2.34 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Product Documents for PKC 412

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for PKC 412

For research use only

Related Research Areas

Diabetes
Intracellular Kinases

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