Catalog Number: 2992
Alternate Names: CGP 41251
Chemical Name: [9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide
Biological Activity
Broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.
Technical Data
  • M.Wt:
    570.64
  • Formula:
    C35H30N4O4
  • Solubility:
    Soluble to 15 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    120685-11-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. PKC412 - a protein kinase inhibitor with a broad therapeutic potential.
    Fabbro et al.
    Anticancer Drug Des., 2000;15:17
  2. The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C.
    Tenzer et al.
    Cancer Res., 2001;61:8203
  3. PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts.
    Nakazono-Kusaba et al.
    Eur.J.Pharmacol., 2004;497:155
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PKC 412 include:

3 Citations: Showing 1 - 3
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  1. Ets and GATA Transcription Factors Play a Critical Role in PMA-Mediated Repression of the ckβ Promoter via the Protein Kinase C Signaling Pathway.
    Authors: Kuan Et al.
    PLoS One 2014;9:e113485
  2. H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling.
    Authors: Woolley Et al.
    PLoS One 2012;7:e34050
  3. The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11).
    Authors: Wasag Et al.
    Haematologica 2011;96:922

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