Broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α
, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.
Soluble to 15 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
PKC412 - a protein kinase inhibitor with a broad therapeutic potential.
Fabbro et al.
Anticancer Drug Des., 2000;15:17
The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C.
Tenzer et al.
Cancer Res., 2001;61:8203
PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts.
Nakazono-Kusaba et al.
The citations listed below are publications that use Tocris products. Selected citations for PKC 412 include:
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