Catalog Number: 2992
Alternate Names: CGP 41251
Chemical Name: [9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide
Biological Activity
Broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 15 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. PKC412 - a protein kinase inhibitor with a broad therapeutic potential.
    Fabbro et al.
    Anticancer Drug Des., 2000;15:17
  2. The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C.
    Tenzer et al.
    Cancer Res., 2001;61:8203
  3. PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts.
    Nakazono-Kusaba et al.
    Eur.J.Pharmacol., 2004;497:155
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