Dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. Enables propagation of undifferentiated murine ESCs in the absence of leukemia inhibitory factor (LIF).
Soluble to 25 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Self-renewal of embryonic stem cells by a small molecule.
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A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept.
Mertins et al.
PLoS One, 2013;8:e57099
Applying chemical tools to the discovery of novel regenerative medicine.
Wu and Ding et al.
Drug Discov.Today Technol., 2006;3:255