Catalog Number: 4433
Alternate Names: SC1
Chemical Name: N-[3-[7-[(1,3-Dimethyl-1H-pyrazol-5-yl)amino]-1,4-dihydro-1-methyl-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide
Biological Activity
Dual inhibitor of extracellular signal-regulated kinase 1 (ERK1, MAPK3) and RasGAP. Maintains embryonic stem cell (ESC) self-renewal. Enables propagation of undifferentiated murine ESCs in the absence of leukemia inhibitory factor (LIF).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Self-renewal of embryonic stem cells by a small molecule.
    Chen et al.
    Proc.Natl.Acad.Sci.USA, 2006;103:17266
  2. A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept.
    Mertins et al.
    PLoS One, 2013;8:e57099
  3. Applying chemical tools to the discovery of novel regenerative medicine.
    Wu and Ding et al.
    Drug Discov.Today Technol., 2006;3:255
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