Chemical Name: 2-Chloro-10-[3[(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine dimaleate
Biological ActivityD2 receptor antagonist. Also interacts with 5-HT3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo.
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Radioligand binding and photoaffinity labeling studies show a direct interaction of phenothiazenes at 5-HT3 receptors.
Lummis and Baker
Prochlorperazine induces central antinociception mediated by the muscarinic system.
Ghelardini et al.
The antipsychotic and antiemetic drug prochlorper. delays the ventricular repolarization of the in situ canine heart.
Satoh et al.
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