Chemical Name: 2-Chloro-10-[3[(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine dimaleate
Biological ActivityD2 receptor antagonist. Also interacts with 5-HT3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Radioligand binding and photoaffinity labeling studies show a direct interaction of phenothiazenes at 5-HT3 receptors.
Lummis and Baker
Prochlorperazine induces central antinociception mediated by the muscarinic system.
Ghelardini et al.
The antipsychotic and antiemetic drug prochlorper. delays the ventricular repolarization of the in situ canine heart.
Satoh et al.
Citation for Prochlorperazine dimaleate
The citations listed below are publications that use Tocris products. Selected citations for Prochlorperazine dimaleate include:
1 Citation: Showing 1 - 1
Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.
Authors: Kenny Et al.
Proc Natl Acad Sci U S A 2015;6:6220
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