Prochlorperazine dimaleate

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3287/100
Prochlorperazine dimaleate | CAS No. 84-02-6 | Dopamine D2 Receptor Antagonists
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Description: D2 receptor antagonist; also 5-HT3 and nAChR antagonist

Chemical Name: 2-Chloro-10-[3[(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine dimaleate

Purity: ≥99%

Product Details
Citations (1)
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Reviews

Biological Activity

D2 receptor antagonist. Also interacts with 5-HT3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo.

Technical Data

M.Wt:
606.09
Formula:
C20H24ClN3S.2C4H4O4
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
84-02-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Radioligand binding and photoaffinity labeling studies show a direct interaction of phenothiazenes at 5-HT3 receptors.
    Lummis and Baker
    Neuropharmacology, 1997;36:665
  2. Prochlorperazine induces central antinociception mediated by the muscarinic system.
    Ghelardini et al.
    Pharmacol.Res., 2004;50:351
  3. The antipsychotic and antiemetic drug prochlorper. delays the ventricular repolarization of the in situ canine heart.
    Satoh et al.
    J.Pharm.Sci., 2005;97:101

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Citation for Prochlorperazine dimaleate

The citations listed below are publications that use Tocris products. Selected citations for Prochlorperazine dimaleate include:

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