Catalog Number: 3287
Chemical Name: 2-Chloro-10-[3[(4-methyl-1-piperazinyl)propyl]-10H-phenothiazine dimaleate
Biological Activity
D2 receptor antagonist. Also interacts with 5-HT3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 25 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Radioligand binding and photoaffinity labeling studies show a direct interaction of phenothiazenes at 5-HT3 receptors.
    Lummis and Baker
    Neuropharmacology, 1997;36:665
  2. Prochlorperazine induces central antinociception mediated by the muscarinic system.
    Ghelardini et al.
    Pharmacol.Res., 2004;50:351
  3. The antipsychotic and antiemetic drug prochlorperazine delays the ventricular repolarization of the in situ canine heart.
    Satoh et al.
    J.Pharm.Sci., 2005;97:101

The citations listed below are publications that use Tocris products. Selected citations for Prochlorperazine dimaleate include:

Showing Results 1 - 1 of 1

  1. Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy.
    Authors: Kenny Et al.
    Proc Natl Acad Sci U S A
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