Catalog Number: 5792
Biological Activity
Potent Nav1.7 blocker (IC50 = 2.5 nM). Also inhibits Nav1.1, Nav1.2, Nav1.3 and Nav1.6 in the nanomolar range. Exhibits no effects on Cav channels or nAChR at 5 μM. Demonstrates analgesic activity in vivo; antagonizes effects of scorpion-venom toxin OD1 at Nav1.7.
Technical Data
  • M.Wt:
    3802.41
  • Formula:
    C162H246N52O43S6
  • Sequence:
    DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI

    (Modifications: Disulfide bridge: 2-17, 9-22, 16-29, Ile-33 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula thrixopelma pruriens.
    Cardoso et al.
    Mol.Pharmacol., 2015;88:291

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