1.7 blocker (IC50
= 2.5 nM). Also inhibits Nav
1.3 and Nav
1.6 in the nanomolar range. Exhibits no effects on Cav
channels or nAChR at 5 μ
M. Demonstrates analgesic activity in vivo
; antagonizes effects of scorpion-venom toxin OD1 at Nav
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification and characterization of ProTx-III [μ-TRTX-Tp1a], a new voltage-gated sodium channel inhibitor from venom of the tarantula thrixopelma pruriens.
Cardoso et al.