PTAC oxalate
Chemical Name: (1R,5R,6R)-6-[4-(Propylthio)-1,2,5-thiadiazol-3-yl]-1-azabicyclo[3.2.1]octane oxalate
Purity: ≥98%
Biological Activity
Muscarinic receptor ligand. Displays partial agonist activity at M2 and M4 receptors; exhibits antagonist effects at M1, M3 and M5 receptors (Ki values are 2.8, 0.2, 0.6, 0.2 and 0.8 nM respectively). Displays selectivity for muscarinic receptors over a range of neurotransmitter receptors and ion channels. Inhibits firing rate of dopaminergic cells in the limbic ventral tegmental area after acute administration, without binding to dopamine receptors.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Towards a muscarinic hypothesis of schizophrenia.
Raedler et al.
Mol.Psychiatry, 2007;12:232 -
Muscarinic receptor agonists, like DA receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats.
Shannon et al.
J.Pharmacol.Exp.Ther., 1999;290:901 -
Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane.
Bymaster et al.
Eur.J.Pharmacol., 1998;356:109
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Citation for PTAC oxalate
The citations listed below are publications that use Tocris products. Selected citations for PTAC oxalate include:
1 Citation: Showing 1 - 1
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The Analgesic Effects of (5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain.
Authors: Wang Et al.
Anesth Analg 2017;124:1330
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