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Catalog Number:4533
Chemical Name:(1R,5R,6R)-6-[4-(Propylthio)-1,2,5-thiadiazol-3-yl]-1-azabicyclo[3.2.1]octane oxalate
Product Details
Citations (1)
Supplemental Products
Reviews
Biological Activity
Muscarinic receptor ligand. Displays partial agonist activity at M2 and M4 receptors; exhibits antagonist effects at M1, M3 and M5 receptors (Ki values are 2.8, 0.2, 0.6, 0.2 and 0.8 nM respectively). Displays selectivity for muscarinic receptors over a range of neurotransmitter receptors and ion channels. Inhibits firing rate of dopaminergic cells in the limbic ventral tegmental area after acute administration, without binding to dopamine receptors.
Muscarinic receptor ligand. Displays partial agonist activity at M2 and M4 receptors; exhibits antagonist effects at M1, M3 and M5 receptors (Ki values are 2.8, 0.2, 0.6, 0.2 and 0.8 nM respectively). Displays selectivity for muscarinic receptors over a range of neurotransmitter receptors and ion channels. Inhibits firing rate of dopaminergic cells in the limbic ventral tegmental area after acute administration, without binding to dopamine receptors.
Technical Data
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M.Wt:359.46
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Formula:C12H19N3S2.C2H2O4
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Solubility:Soluble to 100 mM in water and to 100 mM in DMSO
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Purity:>98
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Storage:Desiccate at RT
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CAS No:201939-40-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Product Datasheets
Citations:
The citations listed below are publications that use Tocris products. Selected citations for PTAC oxalate include:
1 Citations: Showing 1 - 1
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VersaClone cDNA Plasmids
Description
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Human CHRM2 (NP_000730) VersaClone cDNA
RDC0601
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Human CHRM1 (NP_000729) VersaClone cDNA
RDC0600
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Human CHRM3 (NP_000731) VersaClone cDNA
RDC0602
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Human CHRM4 (NP_000732) VersaClone cDNA
RDC0603
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Human CHRM5 (AAH41805) VersaClone cDNA
RDC0604
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