PTAC oxalate

Biological Activity

Muscarinic receptor ligand. Displays partial agonist activity at M₂ and M₄ receptors; exhibits antagonist effects at M₁, M₃ and M₅ receptors (K_i values are 2.8, 0.2, 0.6, 0.2 and 0.8 nM respectively). Displays selectivity for muscarinic receptors over a range of neurotransmitter receptors and ion channels. Inhibits firing rate of dopaminergic cells in the limbic ventral tegmental area after acute administration, without binding to dopamine receptors.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

1. Towards a muscarinic hypothesis of schizophrenia.
   Raedler et al.
   Mol.Psychiatry, 2007;12:232
2. Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats.
   Shannon et al.
   J.Pharmacol.Exp.Ther., 1999;290:901
3. Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane.
   Bymaster et al.
   Eur.J.Pharmacol., 1998;356:109

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