Recombinant Human FUBI/MNSF beta Protein, CF

R&D Systems | Catalog # UL-930

R&D Systems
Discontinued Product
UL-930 has been discontinued. View all FUBI/MNSF beta products.

Key Product Details

Source

E. coli

Accession Number

P35544

Applications

Enzyme Activity
View all FUBI/MNSF beta Proteins and Enzymes »

Product Specifications

Source

E. coli-derived human FUBI/MNSF beta protein

Purity

>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.

Predicted Molecular Mass

7.8 kDa

Activity

Bioassay data are not available.

Formulation, Preparation, and Storage

UL-930
Formulation

X mg/ml (X μM) in 50 mM HEPES pH 8.0, 100 mM NaCl, 1 mM DTT
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 3 months, -20 to -70 °C under sterile conditions after opening.

Background: FUBI/MNSF beta

The ubiquitin-like protein FUBI/ MNSF beta (Monoclonal Nonspecific Suppressor Factor Beta) is encoded by the FAU gene, and is translated as a pro-form consisting of FUBI fused to the ribosomal S30 protein. S30 is cleaved in a post-translational reaction, releasing the mature 74 amino acid FUBI/MNSF beta protein. FUBI has a C-terminal gly-gly motif common to many ubiquitin-like proteins.

FUBI/ MNSF beta conjugation to Bcl-G has been shown to regulate the ERK1/2-MAPK cascade in macrophage cell lines, and may be implicated in TLR4-mediated signal transduction. Conjugation to endophilin II regulates dectin-1-mediated phagocytosis and inflammatory responses, and may be implicated in TLR2 signaling pathway.

References

    1. Rossman,T.G. et al. (2003) Oncogene 22: 1817-1821
    2. Nakamura, M. & Omura, S. (2008) Biosci. Biotech. Biochem. 72: 1915-1920
    3. Nakamura, M. & Yamaguchi, S. (2006) J. Biol. Chem. 281: 16861-16969
    4. Nakamura, M & Watanabe, N. (2010) Biochem, Biophys. Res. Comm. 15: 275-61
    5. Nakamura, M. et al. (2012) Mol. Cell Biochem. 364:39-43

Alternate Names

40S Ribosomal Protein S30, asr1, FAU, Fub1, MNSFbeta, RPS30, S30

Entrez Gene IDs

2197 (Human); 100039316 (Mouse); 29752 (Rat)

Gene Symbol

FAU

UniProt

P35544

Additional FUBI/MNSF beta Products

Product Documents for Recombinant Human FUBI/MNSF beta Protein, CF

Certificate of Analysis

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Product Specific Notices for Recombinant Human FUBI/MNSF beta Protein, CF

For research use only

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