TLR4 agonist. Promotes NF-κ
B nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro
. Acts as an adjuvant in vivo
; enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Intranasal vaccination against HIV-1 with adenoviral vector-based nanocomplex using synthetic TLR-4 agonist peptide as adjuvant.
Li et al.
Synthetic Toll like receptor-4 (TLR-4) agonist peptides as a novel class of adjuvants.
Shanmugam et al.
PLoS One, 2012;7:e30839