RS 09
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Description: TLR4 peptide agonist; acts as an adjuvant in vivo
Biological Activity
TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enhances X-15 specific antibody serum concentrations, when administered with X-15-KLH in mice.Technical Data
M.Wt:
691.78
Formula:
C31H49N9O9
Sequence:
APPHALS
Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
1449566-36-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Intranasal vaccination against HIV-1 with adenoviral vector-based nanocomplex using synthetic TLR-4 agonist peptide as adjuvant.
Li et al.
Mol.Pharm., 2016;13:885 -
Synthetic Toll like receptor-4 (TLR-4) agonist peptides as a novel class of adjuvants.
Shanmugam et al.
PLoS One, 2012;7:e30839
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