Selective protease-activated receptor-1 (PAR1
) antagonist; displays no activity at PAR2
, or PAR4
subtypes. Blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Also inhibits angiogenesis in a chick embryo angiogenesis model in vivo
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Design, synthesis and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor.
Andrade-Gordon et al.
Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, protease-activated receptor-1 (PAR-1).
Maryanoff et al.
Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis.
Zania et al.
The citations listed below are publications that use Tocris products. Selected citations for RWJ 56110 include:
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