(S)-(+)-Niguldipine hydrochloride

Key Product Details

Product Description

(S)-(+)-Niguldipine hydrochloride is a L-type Ca²⁺ channel blocker and α_1A-adrenoceptor antagonist; more active enantiomer.

R-enantiomer also available.

Product Specifications for (S)-(+)-Niguldipine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (S)-(+)-Niguldipine hydrochloride

The following data is based on the product molecular weight 646.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.55 mL	7.74 mL	15.48 mL
5 mM	0.31 mL	1.55 mL	3.10 mL
10 mM	0.15 mL	0.77 mL	1.55 mL
50 mM	0.03 mL	0.15 mL	0.31 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wetzel Discovery of alpha_1a-adrenergic receptor antagonists based on the L-type Ca²⁺ channel antagonist niguldipine. J.Med.Chem. 1995 PMID: 7752182
• Graziadei Stereoselective binding of niguldipine enantiomers to alpha_1A-adrenoceptors labeled with [³H]5-methyl-urapidil. Eur.J.Pharmacol. 1989 PMID: 2555206
• Hollt Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein. Biochem.Pharmacol. 1992 PMID: 1352973
• Boer (+)-Niguldipine binds with very high affinity to Ca²⁺ channels and to a subtype of alpha₁-adrenoceptor. Eur.J.Pharmacol. 1989 PMID: 2548881

Product Documents for (S)-(+)-Niguldipine hydrochloride