SAHM1

Name: SAHM1
Brand: Tocris Bioscience
SKU: 6477

Tocris Bioscience | Catalog # 6477

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Product Documents

Notch pathway inhibitor; prevents Notch complex assembly

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Discontinued Product

6477 has been discontinued. View all Notch Signaling Inhibitors products.

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Notch pathway inhibitor; prevents Notch complex assembly

View all Notch Signaling Inhibitors »

Product Description

SAHM1 is a notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.

Product Specifications for SAHM1

Molecular Weight

2196.58

Formula

C₉₄H₁₆₂N₃₆O₂₃S

Storage

Store at -20°C

Purity

≥90% (HPLC)

CAS Number

2050906-89-1

PubChem ID

137919859

InChI Key

ADWKVIAAKDSBNE-VHQDTIAVSA-N

SMILES

[H]N([C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)[C@]1(C)CCC\C=C/CCC[C@](C)(NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(C)=O)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

Calculators

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Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

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Concentration 1 (C1)

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Concentration 2 (C2)

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The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background References

References are publications that support the biological activity of the product.

Bagheri Notch pathway is active during osteogenic differentiation of human bone marrow mesenchymal stem cells induced by pulsed electromagnetic fields. J.Tissue Eng.Regen.Med. 2018 PMID: 28482141
KleinJan The Notch pathway inhibitor stapled a-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. J.Allergy Clin.Immunol. 2018 PMID: 29111218
Ashley Notch signaling promotes osteoclast maturation and resorptive activity. J Cell Biochem 2015 PMID: 25914241

Product Documents for SAHM1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for SAHM1

For research use only

Related Research Areas

Notch Pathway

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