Biological ActivityNotch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.
(Modifications: Ala-1 = N-terminal Ac, Ala-1 = β-Ala, X = (S)-2-(4-pentenyl)alanine, X-9 and X-13 stapled together with a double bond)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Notch signaling promotes osteoclast maturation and resorptive activity.
Ashley et al.
J Cell Biochem, 2015;116:2598
Notch pathway is active during osteogenic differentiation of human bone marrow mesenchymal stem cells induced by pulsed electromagnetic fields.
Bagheri et al.
J.Tissue Eng.Regen.Med., 2018;12:304
The Notch pathway inhibitor stapled a-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma.
KleinJan et al.
J.Allergy Clin.Immunol., 2018;142:76
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