SB 200646 hydrochloride

Key Product Details

Product Description

SB 200646 hydrochloride is a 5-HT_2C/2B receptor antagonist, selective over 5-HT_1A. Affinities are 7.4 (pA₂), 6.9 (pK_i) and 5.2 (pK_i) for 5-HT_2B, _2C and _2A respectively. Orally active in vivo.

Licensing Information

Sold under license

Product Specifications for SB 200646 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 200646 hydrochloride

The following data is based on the product molecular weight 302.76.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.30 mL	16.51 mL	33.03 mL
5 mM	0.66 mL	3.30 mL	6.61 mL
10 mM	0.33 mL	1.65 mL	3.30 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Kennett In vivo properties of SB 200646A, a 5-HT_2C/2B recepor antagonist. Br.J.Pharmacol. 1994 PMID: 7912626
• Kennett Effect of SB 200646A, a 5-HT_2C/5-HT_2B receptor antagonist, in two conflict models of anxiety. Psychopharmacology (Berl.) 1995 PMID: 7617805
• Forbes N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT_1C receptor antagonist. J.Med.Chem. 1993 PMID: 8478907

Product Documents for SB 200646 hydrochloride