Catalog Number: 1371
Chemical Name: N-(1-Methyl-1H-indol-5-yl)-N'-3-pyridinylurea
Biological Activity
5-HT2C/2B receptor antagonist, selective over 5-HT1A. Affinities are 7.4 (pA2), 6.9 (pKi) and 5.2 (pKi) for 5-HT2B, 2C and 2A respectively. Orally active in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license
Background References
  1. N-(1-Methyl-5-indolyl)-N'-(3-pyridyl)urea hydrochloride: the first selective 5-HT1C receptor antagonist.
    Forbes et al.
    J.Med.Chem., 1993;36:1104
  2. In vivo properties of SB 200646A, a 5-HT2C/2B recepor antagonist.
    Kennett et al.
    Br.J.Pharmacol., 1994;111:797
  3. Effect of SB 200646A, a 5-HT2C/5-HT2B receptor antagonist, in two conflict models of anxiety.
    Kennett et al.
    Psychopharmacology (Berl.), 1995;118:178

The citations listed below are publications that use Tocris products. Selected citations for SB 200646 hydrochloride include:

1 Citations: Showing 1 - 1

  1. Release of glutamate and CGRP from trigeminal ganglion neurons: Role of calcium channels and 5-HT1 receptor signaling.
    Authors: Xiao Et al.
    Am J Physiol Endocrinol Metab 2008;4:12

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