Catalog Number: 1376
Chemical Name: (R)-[[2-Phenyl-4-quinolinyl)carbonyl]amino]-methyl ester benzeneacetic acid
Biological Activity
Potent, selective and competitive non-peptide NK3 receptor antagonist (Ki = 13 nM at hNK3). Displays 90-fold and 7000-fold selectivity over hNK2 and hNK1 receptors respectively. Active in vivo, inhibiting agonist-induced pupillary constriction.
Technical Data
  • M.Wt:
    396.44
  • Formula:
    C25H20N2O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    174635-53-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license
Background References
  1. Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework.
    Giardina et al.
    J.Med.Chem., 1997;40:1794
  2. In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.
    Medhurst et al.
    Br.J.Pharmacol., 1997;122:469
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 218795 include:

2 Citations: Showing 1 - 2
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  1. Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine.
    Authors: Wang Et al.
    Am J Physiol Gastrointest Liver Physiol 2014;307:G719
  2. The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1β, IL-23, and TNF-like 1A expression by monocytes.
    Authors: Cunin Et al.
    J Immunol 2011;186:4175

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