Chemical Name: (R)-[[2-Phenyl-4-quinolinyl)carbonyl]amino]-methyl ester benzeneacetic acid
Biological ActivitySB 218795 is a potent, selective and competitive non-peptide NK3 receptor antagonist (Ki = 13 nM at hNK3). Displays 90-fold and 7000-fold selectivity over hNK2 and hNK1 receptors respectively. Active in vivo, inhibiting agonist-induced pupillary constriction.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Discovery of a novel class of selective non-peptide antagonists for the human neurokinin-3 receptor. 1. Identification of the 4-quinolinecarboxamide framework.
Giardina et al.
In vitro and in vivo characterization of NK3 receptors in the rabbit eye by use of selective non-peptide NK3 receptor antagonists.
Medhurst et al.
Citations for SB 218795
The citations listed below are publications that use Tocris products. Selected citations for SB 218795 include:
4 Citations: Showing 1 - 4
Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X?, P2X?, P2X? channels, P2Y and A? metabotropic receptors in neurotransmission.
Authors: Liñán-Rico Et al.
Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine.
Authors: Wang Et al.
Am J Physiol Gastrointest Liver Physiol 2014;307:G719
Contractile effect of tachykinins on rabbit small intestine.
Authors: Valero Et al.
Acta Pharmacol Sin 2011;32:487
The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1β, IL-23, and TNF-like 1A expression by monocytes.
Authors: Cunin Et al.
J Immunol 2011;186:4175
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