SB 218795

  ( 4 citations )    
Product Datasheet
Catalog Number:1376
Chemical Name:(R)-[[2-Phenyl-4-quinolinyl)carbonyl]amino]-methyl ester benzeneacetic acid
Product Details
Citations (4)
Supplemental Products
Reviews
Biological Activity
Potent, selective and competitive non-peptide NK3 receptor antagonist (Ki = 13 nM at hNK3). Displays 90-fold and 7000-fold selectivity over hNK2 and hNK1 receptors respectively. Active in vivo, inhibiting agonist-induced pupillary constriction.
Technical Data
  • M.Wt:
    396.44
  • Formula:
    C25H20N2O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    174635-53-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license
Product Datasheets
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 218795 include:

4 Citations: Showing 1 - 4
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  1. Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X?, P2X?, P2X? channels, P2Y and A? metabotropic receptors in neurotransmission.
    Authors: Liñán-Rico Et al.
    Neuropharmacology  2015;95:83
  2. Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine.
    Authors: Wang Et al.
    Am J Physiol Gastrointest Liver Physiol  2014;307:G719
  3. Contractile effect of tachykinins on rabbit small intestine.
    Authors: Valero Et al.
    Acta Pharmacol Sin  2011;32:487
  4. The tachykinins substance P and hemokinin-1 favor the generation of human memory Th17 cells by inducing IL-1β, IL-23, and TNF-like 1A expression by monocytes.
    Authors: Cunin Et al.
    J Immunol  2011;186:4175

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