SB 243213 dihydrochloride

Key Product Details

Product Description

SB 243213 dihydrochloride is a selective 5-HT_2C inverse agonist (pK_b = 9.8). Displays selectivity over other 5-HT₂ subtypes (pK_i values are 6.8, 7.0 and 9.0 for 5-HT_2A, 5-HT_2B and 5-HT_2C respectively); also exhibits >100-fold selectivity over 50 other receptors, ion channels and enzymes. Displays anxiolytic activity in rat models.

Product Specifications for SB 243213 dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 243213 dihydrochloride

The following data is based on the product molecular weight 501.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.99 mL	19.95 mL	39.89 mL
2.5 mM	0.80 mL	3.99 mL	7.98 mL
5 mM	0.40 mL	1.99 mL	3.99 mL
25 mM	0.08 mL	0.40 mL	0.80 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

• Wood SB-243213; a selective 5-HT_2C receptor inverse agonist with improved anxiolytic profile: lack of tolderance and withdrawal anxiety. Neuropharmacology 2001 PMID: 11489455
• Berg Differential effects of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxyl]-5-pyridyl]carbamoyl]-6-trifluoromethylindone (SB 243213) on 5-hydroxytryptamine_2C receptor-mediated responses. J.Pharmacol.Exp.Ther. 2006 PMID: 16807362
• Bromidge Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic a J.Med.Chem. 2000 PMID: 10737744

Product Documents for SB 243213 dihydrochloride