SB 243213 dihydrochloride
Discontinued Product
Chemical Name: 2,3-Dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-6-(trifluoromethyl)-1H-Indole-1-carboxamide dihydrochloride
Purity: ≥99%
Biological Activity
SB 243213 dihydrochloride is a selective 5-HT2C inverse agonist (pKb = 9.8). Displays selectivity over other 5-HT2 subtypes (pKi values are 6.8, 7.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C respectively); also exhibits >100-fold selectivity over 50 other receptors, ion channels and enzymes. Displays anxiolytic activity in rat models.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolderance and withdrawal anxiety.
Wood et al.
Neuropharmacology, 2001;41:186 -
Differential effects of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxyl]-5-pyridyl]carbamoyl]-6-trifluoromethylindone (SB 243213) on 5-hydroxytryptamine2C receptor-mediated responses.
Berg et al.
J.Pharmacol.Exp.Ther., 2006;319:260 -
Biarylcarbamoylindolines are novel and selective 5-HT2C receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic a
Bromidge et al.
J.Med.Chem., 2000;43:1123
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for SB 243213 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for SB 243213 dihydrochloride include:
1 Citation: Showing 1 - 1
-
Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis.
Authors: Ward Et al.
Nat Commun 2015;290:12844
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for SB 243213 dihydrochloride
There are currently no reviews for this product. Be the first to review SB 243213 dihydrochloride and earn rewards!
Have you used SB 243213 dihydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
