Catalog Number: 4398
Chemical Name: (2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone
Biological Activity
Allosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.
Technical Data
  • M.Wt:
    276.33
  • Formula:
    C18H16N2O
  • Solubility:
    Soluble to 75 mM in DMSO and to 75 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    871361-88-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.
    Jo et al.
    Proc.Natl.Acad.Sci.USA, 2011;108:6486
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SC 66 include:

1 Citations: Showing 1 - 1

  1. p22phox confers resistance to cisplatin, by blocking its entry into the nucleus.
    Authors: Hung Et al.
    J Cell Biol 2015;6:4110

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