Chemical Name: (2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone
Biological ActivityAllosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.
Jo et al.
Citations for SC 66
The citations listed below are publications that use Tocris products. Selected citations for SC 66 include:
2 Citations: Showing 1 - 2
HPV16-Immortalized Cells from Human Transformation Zone and Endocervix are More Dysplastic than Ectocervical Cells in Organotypic Culture.
Authors: Deng Et al.
Sci Rep 2018;8:15402
p22phox confers resistance to cisplatin, by blocking its entry into the nucleus.
Authors: Hung Et al.
J Cell Biol 2015;6:4110
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
VersaClone cDNA Plasmids
Reviews for SC 66
Average Rating: 5 (Based on 1 Review)
Have you used SC 66?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
MG-63 cells were treated with LPA (10 µM) alone or in the presence of SC 66 (0-10 µM) for 3 h to follow COX-2 expression using Western blot. SC 66 inhibited LPA-induced COX-2 expression in a concentration dependent manner starting from 5 µM.