SC 66
Chemical Name: (2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone
Purity: ≥98%
Biological Activity
SC 66 is an allosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.
Jo et al.
Proc.Natl.Acad.Sci.USA, 2011;108:6486
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Citations for SC 66
The citations listed below are publications that use Tocris products. Selected citations for SC 66 include:
2 Citations: Showing 1 - 2
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HPV16-Immortalized Cells from Human Transformation Zone and Endocervix are More Dysplastic than Ectocervical Cells in Organotypic Culture.
Authors: Deng Et al.
Sci Rep 2018;8:15402
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p22phox confers resistance to cisplatin, by blocking its entry into the nucleus.
Authors: Hung Et al.
J Cell Biol 2015;6:4110
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MG-63 cells were treated with LPA (10 µM) alone or in the presence of SC 66 (0-10 µM) for 3 h to follow COX-2 expression using Western blot. SC 66 inhibited LPA-induced COX-2 expression in a concentration dependent manner starting from 5 µM.
