SC 66

Catalog # Availability Size / Price Qty
4398/10
4398/50
Akt (Protein Kinase B) Inhibitors Small Molecule
1 Image
Description: Allosteric Akt inhibitor

Chemical Name: (2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone

Purity: ≥98%

Product Details
Citations (2)
Supplemental Products
Reviews (1)

Biological Activity

Allosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.

Technical Data

M.Wt:
276.33
Formula:
C18H16N2O
Solubility:
Soluble to 75 mM in DMSO and to 75 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
871361-88-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for SC 66

The citations listed below are publications that use Tocris products. Selected citations for SC 66 include:

2 Citations: Showing 1 - 2

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SC 66 inhibits LPA induced COX-2 in osteosarcoma cells
By Christopher Trummer on 10/23/2018
Species: Human

MG-63 cells were treated with LPA (10 µM) alone or in the presence of SC 66 (0-10 µM) for 3 h to follow COX-2 expression using Western blot. SC 66 inhibited LPA-induced COX-2 expression in a concentration dependent manner starting from 5 µM.


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