SC 66

Tocris Bioscience | Catalog # 4398

Allosteric Akt inhibitor
Tocris Bioscience
Discontinued Product
4398 has been discontinued. View all Akt (Protein Kinase B) Inhibitors products.

Key Product Details

Description

Allosteric Akt inhibitor
View all Akt (Protein Kinase B) Inhibitors »

Product Description

SC 66 is an allosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.

Product Specifications for SC 66

Molecular Weight

276.33

Formula

C18H16N2O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

(2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone

CAS Number

871361-88-5

PubChem ID

6018993

InChI Key

CYVVJSKZRBZHAV-UNZYHPAISA-N

SMILES

O=C(/C(CCC3)=C/C2=CC=NC=C2)/C3=C/C1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 20.72 75
Ethanol 20.72 75

Preparing Stock Solutions for SC 66

The following data is based on the product molecular weight 276.33.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.75 mM 4.83 mL 24.13 mL 48.25 mL
3.75 mM 0.97 mL 4.83 mL 9.65 mL
7.5 mM 0.48 mL 2.41 mL 4.83 mL
37.5 mM 0.10 mL 0.48 mL 0.97 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SC 66

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SC 66

For research use only

Customer Reviews for SC 66 (1)

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  • SC 66 inhibits LPA induced COX-2 in osteosarcoma cells
    Name: Christopher Trummer
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    Verified Customer | Posted 10/23/2018
    MG-63 cells were treated with LPA (10 µM) alone or in the presence of SC 66 (0-10 µM) for 3 h to follow COX-2 expression using Western blot. SC 66 inhibited LPA-induced COX-2 expression in a concentration dependent manner starting from 5 µM.
    SC 66 4398

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