Chemical Name: (2E,6E)-2,6-Bis(4-pyridinylmethylene)cyclohexanone
Biological ActivitySC 66 is an allosteric inhibitor of Akt; interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Exhibits anticancer activity in vitro and in vivo.
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Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination.
Jo et al.
Citations for SC 66
The citations listed below are publications that use Tocris products. Selected citations for SC 66 include:
2 Citations: Showing 1 - 2
HPV16-Immortalized Cells from Human Transformation Zone and Endocervix are More Dysplastic than Ectocervical Cells in Organotypic Culture.
Authors: Deng Et al.
Sci Rep 2018;8:15402
p22phox confers resistance to cisplatin, by blocking its entry into the nucleus.
Authors: Hung Et al.
J Cell Biol 2015;6:4110
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VersaClone cDNA Plasmids
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MG-63 cells were treated with LPA (10 µM) alone or in the presence of SC 66 (0-10 µM) for 3 h to follow COX-2 expression using Western blot. SC 66 inhibited LPA-induced COX-2 expression in a concentration dependent manner starting from 5 µM.