Catalog Number: 1516
Chemical Name: 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1H-indole-2-carboxylic acid, 1-methylethyl ester
Biological Activity
β-adrenoceptor and 5-HT1A/1B receptor antagonist. pKB/pA2 values are 8.3 and 8.0 for 5-HT1A and 5-HT1B receptors respectively. Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    348.44
  • Formula:
    C19H28N2O4
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    39731-05-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. VII International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
    Hoyer et al.
    Pharmacol.Rev., 1994;46:157
  2. Evidence for the involvement of 5-HT1A receptors in the anticonflict effect of ipsapirone in rats.
    Chojnacka-Wojcik and Przegalinski
    Neuropharmacology, 1991;30:703
  3. Identity of inhibitory presynaptic 5-hydroxytryptamine (5-HT) autoreceptors in the rat brain cortex with 5-HT1B binding sites.
    Engel et al.
    Naunyn-Schmied.Arch.Pharmacol., 1986;332:1

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