exchanger (NCX) inhibitor. Inhibits NCX activity in rat astrocytes, microglia and cultured neurons, canine cardiac sarcolemmal vesicles and rat cardiomyocytes (IC50
values are 5 and 8.3, 33, 90 and 92 nM, respectively). Reduces infarct volumes and exhibits protective effects against myocardial ischemia in rats.
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All Tocris products are intended for laboratory research use only.
Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia-reperfusion injuries.
Takahashi et al.
Block of Na(+)/Ca(2+) exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation.
Christ et al.
Involvement of Na+-Ca2+ exchanger in cAMP-mediated relaxation in mice aorta: evaluation using transgenic mice.
Karashima et al.