Chemical Name: 2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine
Biological ActivitySEA 0400 is a potent Na+/Ca2+ exchanger (NCX) inhibitor. Inhibits NCX activity in rat astrocytes, microglia and cultured neurons, canine cardiac sarcolemmal vesicles and rat cardiomyocytes (IC50 values are 5 and 8.3, 33, 90 and 92 nM, respectively). Reduces infarct volumes and exhibits protective effects against myocardial ischemia in rats.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Block of Na(+)/Ca(2+) exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation.
Christ et al.
Involvement of Na+-Ca2+ exchanger in cAMP-mediated relaxation in mice aorta: evaluation using transgenic mice.
Karashima et al.
Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia-reperfusion injuries.
Takahashi et al.
Citation for SEA 0400
The citations listed below are publications that use Tocris products. Selected citations for SEA 0400 include:
1 Citation: Showing 1 - 1
NCX1 Represents an Ionic Na+ Sensing Mechanism in Macrophages.
Authors: Neubert Et al.
PLoS Biol 2020;18
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