Biological ActivityPeptide agonist for sst2 and sst5 somatostatin receptors. IC50/Kd values (nM) at cloned human somatostatin receptors are: > 1000 (sst1), 0.2 - 1.5 (sst2), 27 - 36 (sst3), > 127 (sst4), and 0.06 - 23 (sst5).
(Modifications: Ala-1 = N-methyl-Ala, Trp-3 = D-Trp, Cyclized)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Molecular pharmacology of somatostatin receptors.
Hoyer et al.
Naunyn Schmiedebergs Arch.Pharmacol., 1994;350:441
Cloned somatostatin receptors: identification of subtype-selective peptides and demonstration of high affinity binding to linear peptides.
Raynor et al.
Drug design at peptide receptors. Somatostatin receptor ligands.
Hannon et al.
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