Spinorphin
Description: Enkephalin-degrading and ACE inhibitor
Biological Activity
Spinorphin is an endogenous peptide; inhibits enkephalin-degrading enzymes (aminopeptidase, dipeptidyl aminopeptidase III, neprilysin) and angiotensin-converting enzyme. Displays antinociceptive effects in mice.Technical Data
M.Wt:
877.05
Formula:
C45H64N8O10
Sequence:
LVVYPWT
Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
137201-62-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Spinorphin, an endogenous inhibitor of enkephalin-degrading enzymes, potentiates Leu-enkephalin-induced anti-allodynic and antinociceptive effects in mice.
Honda et al.
Jpn.J.Pharmacol., 2001;87:261 -
The endogenous opioid spinorphin blocks fMet-Leu-Phe-induced neutrophil chemotaxis by acting as a specific antagonist at the N-formylpeptide receptor subtype FPR.
Liang et al.
J.Immunol., 2001;167:6609
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