Chemical Name: (4-Chlorophenyl)(dimethoxyphosphinyl)methyl phosphoric acid dimethyl ester
Biological ActivitySR 202 is a selective PPARγ antagonist; antidiabetic and antiobesity agent. Attenuates troglitazone-induced PPARγ transcriptional activity (IC50 = 140 μM) without affecting ligand-stimulated PPARα, PPARβ or FXR transcriptional activity. Inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo. Improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity.
Nguyen et al.
A new selective peroxisome proliferator-activated receptor γ antagonist with antiobesity and antidiabetic activity.
Rieusset et al.
Do peroxisome proliferation receptor-γ antagonists have clinical potential as combined antiobesity and antidiabetic drugs?
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