Catalog Number: 2022
Alternate Names: Mifobate
Chemical Name: (4-Chlorophenyl)(dimethoxyphosphinyl)methyl phosphoric acid dimethyl ester
Biological Activity
Selective PPARγ antagonist; antidiabetic and antiobesity agent. Attenuates troglitazone-induced PPARγ transcriptional activity (IC50 = 140 μM) without affecting ligand-stimulated PPARα, PPARβ or FXR transcriptional activity. Inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo. Improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo.
Technical Data
  • M.Wt:
    358.65
  • Formula:
    C11H17ClO7P2
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    76541-72-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity.
    Nguyen et al.
    J.Med.Chem., 1987;30:1426
  2. A new selective peroxisome proliferator-activated receptor γ antagonist with antiobesity and antidiabetic activity.
    Rieusset et al.
    Mol.Endocrinol., 2002;16:2628
  3. Do peroxisome proliferation receptor-γ antagonists have clinical potential as combined antiobesity and antidiabetic drugs?
    Doggrell
    Expert.Opin.Invest.Drugs, 2003;12:713

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