SR 202

Catalog # Availability Size / Price Qty
2022/10
2022/50
PPAR gamma Receptor Antagonists Small Molecule
1 Image
Description: Selective PPARγ antagonist; antidiabetic and antiobesity agent
Alternative Names: Mifobate

Chemical Name: (4-Chlorophenyl)(dimethoxyphosphinyl)methyl phosphoric acid dimethyl ester

Purity: ≥99%

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Biological Activity

Selective PPARγ antagonist; antidiabetic and antiobesity agent. Attenuates troglitazone-induced PPARγ transcriptional activity (IC50 = 140 μM) without affecting ligand-stimulated PPARα, PPARβ or FXR transcriptional activity. Inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo. Improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo.

Technical Data

M.Wt:
358.65
Formula:
C11H17ClO7P2
Solubility:
Soluble to 100 mM in water
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
76541-72-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. gem-Diphosphonate and gem-phosphonate-phosphate compounds with specific high density lipoprotein inducing activity.
    Nguyen et al.
    J.Med.Chem., 1987;30:1426
  2. A new selective peroxisome proliferator-activated receptor γ antagonist with antiobesity and antidiabetic activity.
    Rieusset et al.
    Mol.Endocrinol., 2002;16:2628
  3. Do peroxisome proliferation receptor-γ antagonists have clinical potential as combined antiobesity and antidiabetic drugs?
    Doggrell
    Expert.Opin.Invest.Drugs, 2003;12:713

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