Calcium sensing receptor (CaSR) agonist. Activates ERK1/2 signaling, intracellular calcium mobilization, and calcitonin secretion. Enhances osteogenic differentiation of mesenchymal stem cells.
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Strontium is a biased agonist of the calcium-sensing receptor in rat medullary thyroid carcinoma 6-23 cells.
Thomsen et al.
Strontium enhances osteogenic differentiation of mesenchymal stem cells and in vivo bone formation by activating Wnt/catenin signaling.
Yang et al.
Stem Cells, 2011;29:981