Catalog Number: 1459
Alternate Names: DMBI
Chemical Name: 3-[[4-(dimethylamino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one
Biological Activity
Potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). Selective over EGFR and c-Src tyrosine kinases.
Technical Data
  • M.Wt:
    264.33
  • Formula:
    C17H16N2O
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Desiccate at -20°C
  • CAS No:
    5812-07-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues.
    Kendall et al.
    J.Biol.Chem., 1999;274:6453
  2. Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor β-receptor (β-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases.
    Zaman et al.
    Biochem.Pharmacol., 1998;57:57
  3. Synthesis and biological evaluations of 3-substituted indol-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases.
    Sun et al.
    J.Med.Chem., 1998;41:2588
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SU 4312 include:

1 Citations: Showing 1 - 1

  1. Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis.
    Authors: Cole Et al.
    PLoS One 2010;5:e11644

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