Potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50
values are 0.8 and 19.4 μ
M respectively). Selective over EGFR and c-Src tyrosine kinases.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues.
Kendall et al.
Tyrosine kinase activity of purified recombinant cytoplasmic domain of platelet-derived growth factor β-receptor (β-PDGFR) and discovery of a novel inhibitor of receptor tyrosine kinases.
Zaman et al.
Synthesis and biological evaluations of 3-substituted indol-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases.
Sun et al.
The citations listed below are publications that use Tocris products. Selected citations for SU 4312 include:
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