T 26c disodium salt

Key Product Details

Product Description

T 26c disodium salt is a highly potent and selective MMP13 inhibitor (IC₅₀ = 6.9 pM). Exhibits >2600-fold selectivity for MMP13 over related MMPs. Inhibits degradation of bovine nasal septum cartilage explants in vitro . Orally bioavailable.

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the T-26c probe summary on the SGC website.

Product Specifications for T 26c disodium salt

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for T 26c disodium salt

The following data is based on the product molecular weight 523.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.10 mL	95.52 mL	191.03 mL
0.5 mM	3.82 mL	19.10 mL	38.21 mL
1 mM	1.91 mL	9.55 mL	19.10 mL
5 mM	0.38 mL	1.91 mL	3.82 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Nara Thieno[2,3-d]pyrimidine-2-carboxamides bearing a carboxybenzene group at 5-position: highly potent, selective, and orally available MMP-13 inhibitors interacting with the S1" binding site. Bioorg.Med.Chem. 2014 PMID: 25192810

Product Documents for T 26c disodium salt