T-peptide

Catalog # Availability Size / Price Qty
6726/1
Microtubule Binding Compounds Peptide
1 Image
Description: Cytotoxic Tau peptide; cell permeable
Product Details
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Biological Activity

Peptide derived from microtubule binding repeat of Tau protein. Self-assembles into 30-55 nm paired helical filaments (PHFs) even in the absense of inducers. Cytotoxic in multiple cell lines including cortical neurons, cerebellar granular neurons, neuroblastoma cells, kidney fibroblasts and HEK293 cells. Co-localizes with pathological hyperphosphorylated forms of tau in vitro. Cell permeable.

Technical Data

M.Wt:
2195.66
Formula:
C92H171N45O18
Sequence:
VQIVYKRRRRRRRRR

(Modifications: Val-1 = N-terminal Ac, Val-1 = D-Val, Gln-2 = D-Gln, Ile-3 = D-Ile, Val-4 = D-Val, Tyr-5 = D-Tyr, Lys-6 = D-Lys, Arg-15 = C-terminal amide)

Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
2022956-62-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Reconstitution Calculator

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