Biological ActivityPeptide derived from microtubule binding repeat of Tau protein. Self-assembles into 30-55 nm paired helical filaments (PHFs) even in the absense of inducers. Cytotoxic in multiple cell lines including cortical neurons, cerebellar granular neurons, neuroblastoma cells, kidney fibroblasts and HEK293 cells. Co-localizes with pathological hyperphosphorylated forms of tau in vitro. Cell permeable.
(Modifications: Val-1 = N-terminal Ac, Val-1 = D-Val, Gln-2 = D-Gln, Ile-3 = D-Ile, Val-4 = D-Val, Tyr-5 = D-Tyr, Lys-6 = D-Lys, Arg-15 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Neuron-selective toxicity of tau peptide in a cell culture model of neurodegenerative tauopathy: essential role for aggregation in neurotoxicity.
Zhao et al.
Novel cell model for tauopathy induced by a cell-permeable tau-related peptide
Veloria et al.
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