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Description: Cytotoxic Tau peptide; cell permeable
Product Details

Biological Activity

Peptide derived from microtubule binding repeat of Tau protein. Self-assembles into 30-55 nm paired helical filaments (PHFs) even in the absense of inducers. Cytotoxic in multiple cell lines including cortical neurons, cerebellar granular neurons, neuroblastoma cells, kidney fibroblasts and HEK293 cells. Co-localizes with pathological hyperphosphorylated forms of tau in vitro. Cell permeable.

Technical Data


(Modifications: Val-1 = N-terminal Ac, Val-1 = D-Val, Gln-2 = D-Gln, Ile-3 = D-Ile, Val-4 = D-Val, Tyr-5 = D-Tyr, Lys-6 = D-Lys, Arg-15 = C-terminal amide)

Soluble to 2 mg/ml in water
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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