Tacrine hydrochloride

Name: Tacrine hydrochloride
Brand: Tocris Bioscience
SKU: 0965
Price: 73 USD

Catalog #: 0965
1 Citation Datasheet / COA / SDS

Discontinued Product

0965 has been discontinued.

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Tacrine hydrochloride | CAS No. 1684-40-8 | Cholinesterase Inhibitors

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Description: Cholinesterase inhibitor

Chemical Name: 1,2,3,4-Tetrahydro-9-aminoacridine hydrochloride

Purity: ≥99%

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Product Details

Citations (1)

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Tacrine hydrochloride is a potent cholinesterase inhibitor, a cognition enhancer in vivo.

Technical Data

M.Wt:

234.73

Formula:

C₁₃H₁₄N₂.HCl

Solubility:

Soluble to 100 mM in water and to 100 mM in DMSO

Purity:

≥99%

Storage:

Desiccate at +4°C

CAS No:

1684-40-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
Tacrine: a pharmacological review.
Freeman and Dawson
Prog.Neurobiol., 1991;36:257
Tetrahydro-9-aminoacridine has mixed actions on muscarinic currents and blocks opioid currents in rat locus ceruleus neurons.
Osborne and Christie
J.Pharmacol.Exp.Ther., 1996;276:137
THA- A review of the literature and its use in treatment of five overdose patients.
Summers and Kaufman
Clin.Toxicol., 1980;16:269
A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donep. and NXX-066.
Snape et al.
Neuropharmacology, 1999;38:181

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Citation for Tacrine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Tacrine hydrochloride include:

1 Citation: Showing 1 - 1

M3 muscarinic acetylcholine receptor expression confers differential cholinergic modulation to neurochemically distinct hippocampal basket cell subtypes.
Authors: Rio Et al.
Mol Cell Endocrinol 2010;30:6011

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