Catalog Number: 0965
Chemical Name: 1,2,3,4-Tetrahydro-5-aminoacridine hydrochloride
Biological Activity
Potent cholinesterase inhibitor, a cognition enhancer in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References

  1. Kishimoto T et al.
    Leucocyte Typing VI. Garland Publishing Inc. London.
  2. Tacrine: a pharmacological review.
    Freeman and Dawson
    Prog.Neurobiol., 1991;36:257
  3. A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066.
    Snape et al.
    Neuropharmacology, 1999;38:181
  4. THA- A review of the literature and its use in treatment of five overdose patients.
    Summers and Kaufman
    Clin.Toxicol., 1980;16:269
  5. Tetrahydro-9-aminoacridine has mixed actions on muscarinic currents and blocks opioid currents in rat locus ceruleus neurons.
    Osborne and Christie
    J.Pharmacol.Exp.Ther., 1996;276:137

The citations listed below are publications that use Tocris products. Selected citations for Tacrine hydrochloride include:

1 Citations: Showing 1 - 1

  1. M3 muscarinic acetylcholine receptor expression confers differential cholinergic modulation to neurochemically distinct hippocampal basket cell subtypes.
    Authors: Rio Et al.
    Mol Cell Endocrinol 2010;30:6011

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