Tacrine hydrochloride

Key Product Details

Product Description

Tacrine hydrochloride is a potent cholinesterase inhibitor, a cognition enhancer in vivo.

Product Specifications for Tacrine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Tacrine hydrochloride

The following data is based on the product molecular weight 234.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

5 4 3 2 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.26 mL	21.30 mL	42.60 mL
5 mM	0.85 mL	4.26 mL	8.52 mL
10 mM	0.43 mL	2.13 mL	4.26 mL
50 mM	0.09 mL	0.43 mL	0.85 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Summers and Kaufman THA- A review of the literature and its use in treatment of five overdose patients. Clin.Toxicol. 1980 PMID: 6994999
• Osborne and Christie Tetrahydro-9-aminoacridine has mixed actions on muscarinic currents and blocks opioid currents in rat locus ceruleus neurons. J.Pharmacol.Exp.Ther. 1996 PMID: 8558423
• Snape A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donep. and NXX-066. Neuropharmacology 1999 PMID: 10193909
• Freeman and Dawson Tacrine: a pharmacological review. Prog.Neurobiol. 1991 PMID: 1714613

Product Documents for Tacrine hydrochloride