Potent JAK3 inhibitor (IC50
= 8 nM). Selective for JAK3 over JAK1, JAK2 and TYK2 (IC50
values are 1017, 2550 and 8055 nM respectively). Also inhibits GSK-3β
values are 3, 13 and 68 nM respectively).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family.
Thoma et al.