TCS 21311

Tocris Bioscience | Catalog # 4221

Potent JAK3 inhibitor. Also inhibits GSK-3β and PKC
Tocris Bioscience
Discontinued Product
4221 has been discontinued. View all JAK Kinase Inhibitors products.

Key Product Details

Description

Potent JAK3 inhibitor. Also inhibits GSK-3β and PKC

Alternative Names

NIBR3049
View all JAK Kinase Inhibitors »

Product Description

TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM). Selective for JAK3 over JAK1, JAK2 and TYK2 (IC50 values are 1017, 2550 and 8055 nM respectively). Also inhibits GSK-3β, PKCα and PKCθ (IC50 values are 3, 13 and 68 nM respectively).

Product Specifications for TCS 21311

Molecular Weight

526.51

Formula

C27H25F3N4O4

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

CAS Number

1260181-14-3

PubChem ID

50925411

InChI Key

CLGRAWDGLMENOD-UHFFFAOYSA-N

SMILES

O=C(N1)C(C3=CNC4=C3C=CC=C4)=C(C2=C(C(F)(F)F)C=CC(N5CCN(C(C(O)(C)C)=O)CC5)=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.65 100

Preparing Stock Solutions for TCS 21311

The following data is based on the product molecular weight 526.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.90 mL 9.50 mL 18.99 mL
5 mM 0.38 mL 1.90 mL 3.80 mL
10 mM 0.19 mL 0.95 mL 1.90 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for TCS 21311

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for TCS 21311

For research use only

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