TCS 21311

Catalog # Availability Size / Price Qty
4221/10
4221/50
TCS 21311 | CAS No. 1260181-14-3 | JAK Kinase Inhibitors
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Description: Potent JAK3 inhibitor. Also inhibits GSK-3β and PKC
Alternative Names: NIBR3049

Chemical Name: 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

Purity: ≥98%

Product Details
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Biological Activity

Potent JAK3 inhibitor (IC50 = 8 nM). Selective for JAK3 over JAK1, JAK2 and TYK2 (IC50 values are 1017, 2550 and 8055 nM respectively). Also inhibits GSK-3β, PKCα and PKCθ (IC50 values are 3, 13 and 68 nM respectively).

Technical Data

M.Wt:
526.51
Formula:
C27H25F3N4O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1260181-14-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of a potent Janus kinase 3 inhibitor with high selectivity within the Janus kinase family.
    Thoma et al.
    J.Med.Chem., 2010;54:284

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