Selective, ATP-competitive Pim kinase inhibitor (IC50
values are 24 and 100 nM for Pim-1 and Pim-2 respectively). Displays selectivity over a panel of ~50 other kinases tested. Exhibits cytotoxicity in PC3 prostate carcinoma cells in vitro
= 17 μ
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Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.
Xia et al.