Chemical Name: 4-(4-Bromo-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-N-(4-iodophenyl)-1-piperidinecarboxamide
Biological ActivityTH 5487 is a selective 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor (IC50 = 342 nM). Selective for OGG1 over other base excision repair enzymes. Inhibits OGG1 binding to 8-oxoG in DNA and suppresses proinflammatory gene expression in TNF-α stimulated lung epithelial cells in vitro. Also inhibits proinflamatory gene expression and neutrophil recruitment in TNF-α-challenged mouse lungs in vivo.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.
Visnes et al.
No product specific FAQs exist for this product, however you mayView all Small Molecule FAQs
Reviews for TH 5487
There are currently no reviews for this product. Be the first to review TH 5487 and earn rewards!
Have you used TH 5487?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image