THPN
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Description: Nur77 agonist; induces autophagy in melanoma cell lines
Chemical Name: 1-(3,4,5-Trihydroxyphenyl)-1-nonanone
Purity: ≥98%
Biological Activity
THPN is a Nur77 agonist. Binds Nur77 and promotes translocation of the receptor to the mitochondria resulting in autophagy in melanoma cell lines.Technical Data
M.Wt:
266.33
Formula:
C15H22O4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
100079-26-3
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Complete Your Research
Background References
-
Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway.
Wang et al.
Nat.Chem.Biol., 2014;10:133 -
Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation.
Li et al.
Nat.Chem.Biol., 2015;11:339
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