Naturally occuring, potent regulator of actin polymerization present in human platelets at a concentration of 200 - 500 μ
M. Sequesters G-actin monomers in a 1:1 ratio (Kd
= 0.7 - 1.0 μ
M) and allows rapid filament polymerization in the presence of profilin. Implicated in wound healing, induction of MMPs, chemotaxis, angiogenesis, inflammatory processes and tumor progression.
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Thymosin β10 and thymosin β4 are both actin monomer sequestering proteins.
Yu et al.
β-thymosins, small acidic peptides with multiple functions.
Huff et al.
Int.J.Biochem.Cell Biol., 2001;33:205
Thymosin β4 and angiogenesis: modes of action and therapeutic potential.
Smart et al.