Toceranib

Key Product Details

Product Description

Toceranib is a potent ATP-competitive PDGFR and VEGFR inhibitor (K_i = 5 and 6 nM, respectively); inhibits phosphorylation of c-Kit and suppresses the growth of mast cell lines expressing mutant Kit, inducing cell cycle arrest and apoptosis. Also inhibits FGFR1 (K_i = 0.5 μM). Effective in vivo.

Licensing Information

Sold for research purposes under agreement from Pfizer.

Product Specifications for Toceranib

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Toceranib

The following data is based on the product molecular weight 396.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.22 mL	126.12 mL	252.23 mL
0.5 mM	5.04 mL	25.22 mL	50.45 mL
1 mM	2.52 mL	12.61 mL	25.22 mL
5 mM	0.50 mL	2.52 mL	5.04 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Liao Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood. 2002 PMID: 12091352

Product Documents for Toceranib