Chemical Name: Tris(dibenzylideneacetone) dipalladium
Biological ActivityN-myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Exhibits antiproliferative activity against melanoma cells in vitro and in vivo. Also used as a cyclization catalyst.
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Tris(Dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo.
Bhandarkar et al.
Clin.Cancer Res., 2008;14:5743
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