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UPF 1069

3736 Datasheet / COA / SDS

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3736 has been discontinued.
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UPF 1069 | CAS No. 1048371-03-4 | Poly(ADP-ribose) Polymerase Inhibitors
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Description: PARP-2 inhibitor

Chemical Name: 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

Purity: ≥99%

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Biological Activity

Selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).

Technical Data

M.Wt:
279.29
Formula:
C17H13NO3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
1048371-03-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.
    Moroni et al.
    Br.J.Pharmacol., 2009;157:854
  2. On the way to selective PARP-2 inhibitors. Design, synthesis and preliminary evaluation of a series of isoquinolinone derivatives.
    Pellicciari et al.
    Chem.Med.Chem, 2008;3:914

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