UPF 1069

Discontinued Product

3736 has been discontinued.
View all Poly(ADP-ribose) Polymerase Inhibitors products.
UPF 1069 | CAS No. 1048371-03-4 | Poly(ADP-ribose) Polymerase Inhibitors
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Description: PARP-2 inhibitor

Chemical Name: 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one

Purity: ≥99%

Product Details

Biological Activity

Selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).

Technical Data

Soluble to 100 mM in DMSO
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage.
    Moroni et al.
    Br.J.Pharmacol., 2009;157:854
  2. On the way to selective PARP-2 inhibitors. Design, synthesis and preliminary evaluation of a series of isoquinolinone derivatives.
    Pellicciari et al.
    Chem.Med.Chem, 2008;3:914

Product Datasheets

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