Vialinin A

Key Product Details

Product Description

Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC₅₀ values are 1.5, 5.9 and 22.3 μM, respectively). Shows no significant inhibition of UCH-L3, USP2, and USP8 activities. Decreases release of TNF-α (IC₅₀ = 0.09 nM) from RBL-2H3 mast cells. Displays anticancer activity decreasing viability in human colonic carcinoma cells. Inhibits VEGF-induced growth and proliferation of HUVECs and production of ROS, cytokines and chemokines in vitro. Also inhibits neovasularization in a mouse model.

Product Specifications for Vialinin A

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Vialinin A

The following data is based on the product molecular weight 562.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	8.89 mL	44.44 mL	88.88 mL
1 mM	1.78 mL	8.89 mL	17.78 mL
2 mM	0.89 mL	4.44 mL	8.89 mL
10 mM	0.18 mL	0.89 mL	1.78 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Sonowal Vialinin A, an edible mushroom-derived p-terphenyl antioxidant, prevents VEGF-induced neovascularization in vitro and in vivo. Oxid Med Cell Longev 2018 PMID: 29541344
• Okada Vialinin A is a ubiquitin-specific peptidase inhibitor. Bioorg.Med.Chem.Lett. 2013 PMID: 23791076
• Onose Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells. Cell Immunol. 2012 PMID: 23246504
• Norikura Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta. J.Agric.Food Chem. 2011 PMID: 21630659

Product Documents for Vialinin A