Chemical Name: 1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) benzeneacetic acid ester
Biological ActivityVialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50 values are 1.5, 5.9 and 22.3 μM, respectively). Shows no significant inhibition of UCH-L3, USP2, and USP8 activities. Decreases release of TNF-α (IC50 = 0.09 nM) from RBL-2H3 mast cells. Displays anticancer activity decreasing viability in human colonic carcinoma cells. Inhibits VEGF-induced growth and proliferation of HUVECs and production of ROS, cytokines and chemokines in vitro. Also inhibits neovasularization in a mouse model.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta.
Norikura et al.
J.Agric.Food Chem., 2011;59:6974
Vialinin A is a ubiquitin-specific peptidase inhibitor.
Okada et al.
Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells.
Onose et al.
Cell Immunol., 2012;279:140
Vialinin A, an edible mushroom-derived p-terphenyl antioxidant, prevents VEGF-induced neovascularization in vitro and in vivo.
Sonowal et al.
Oxid Med Cell Longev, 2018;:1052102
Citation for Vialinin A
The citations listed below are publications that use Tocris products. Selected citations for Vialinin A include:
1 Citation: Showing 1 - 1
USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells.
Authors: Lin Et al.
FEBS Lett 2017;591:1677
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