Home / Microtubule Binding Compounds / Vinorelbine ditartrate

Vinorelbine ditartrate

3401 1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3401/10
3401/50
Vinorelbine ditartrate | CAS No. 125317-39-7 | Microtubule Binding Compounds
1 Image
Description: Selective mitotic microtubule antagonist
Alternative Names: Navelbine

Chemical Name: (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl ester

Purity: ≥97%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.

Technical Data

M.Wt:
1079.1
Formula:
C45H54N4O8.2C4H6O6
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
125317-39-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

COA view current batch
Or select another batch:
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citation for Vinorelbine ditartrate

The citations listed below are publications that use Tocris products. Selected citations for Vinorelbine ditartrate include:

1 Citation: Showing 1 - 1

  1. Metronomic vinorelbine: Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition.
    Authors: Mavroeidis Et al.
    Front Cell Neurosci  2015;47:455

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Vinorelbine ditartrate

There are currently no reviews for this product. Be the first to review Vinorelbine ditartrate and earn rewards!

Have you used Vinorelbine ditartrate?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.