Vinorelbine ditartrate

  ( 1 citations )    
Product Datasheet
Catalog Number:3401
Alternate Names:Navelbine
Chemical Name:(2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl est
Product Details
Citations (1)
Reviews
Biological Activity
Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.
Technical Data
  • M.Wt:
    1079.1
  • Formula:
    C45H54N4O8.2C4H6O6
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >97
  • Storage:
    Store at -20°C
  • CAS No:
    125317-39-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Vinorelbine ditartrate include:

1 Citations: Showing 1 - 1

  1. Metronomic vinorelbine: Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition.
    Authors: Mavroeidis Et al.
    Front Cell Neurosci  2015;47:455

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