Catalog Number: 3401
Alternate Names: Navelbine
Chemical Name: (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl est
Biological Activity
Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.
Technical Data
  • M.Wt:
    1079.1
  • Formula:
    C45H54N4O8.2C4H6O6
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    125317-39-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Vinorelbine (Navelbine): A third generation vinca alkaloid.
    Budman
    Cancer Invest., 1997;15:475
  2. Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic vinca alkaloids vinorelbine and its newer derivative vinflunine.
    Ngan et al.
    Mol.Pharmacol., 2001;60:225
  3. The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics.
    Okouneva et al.
    Mol.Cancer Ther., 2003;2:427
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Vinorelbine ditartrate include:

1 Citations: Showing 1 - 1

  1. Metronomic vinorelbine: Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition.
    Authors: Mavroeidis Et al.
    Front Cell Neurosci 2015;47:455

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