Vinorelbine ditartrate

Tocris Bioscience | Catalog # 3401

Selective mitotic microtubule antagonist
Tocris Bioscience
Discontinued Product
3401 has been discontinued. View all Microtubule Binding Compounds products.

Key Product Details

Description

Selective mitotic microtubule antagonist

Alternative Names

Navelbine
View all Microtubule Binding Compounds »

Product Description

Vinorelbine ditartrate is a selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.

Product Specifications for Vinorelbine ditartrate

Molecular Weight

1079.10

Formula

C45H54N4O8.2C4H6O6

Storage

Store at -20°C

Purity

≥97% (HPLC)

Chemical Name

(2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl ester

CAS Number

125317-39-7

PubChem ID

5311497

InChI Key

GBABOYUKABKIAF-IELIFDKJSA-N

SMILES

[H][C@@]23N(C)C1=CC(OC)=[C@]([C@@](C7=C(C9)C(C=CC=C8)=C8N7)([C@](OC)=O)C[C@]6([H])C=C(CC)CN9C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O.O=C(O)C(O)C(O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 107.91 100
DMSO 107.91 100

Preparing Stock Solutions for Vinorelbine ditartrate

The following data is based on the product molecular weight 1079.10.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.93 mL 4.63 mL 9.27 mL
5 mM 0.19 mL 0.93 mL 1.85 mL
10 mM 0.09 mL 0.46 mL 0.93 mL
50 mM 0.02 mL 0.09 mL 0.19 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for Vinorelbine ditartrate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Vinorelbine ditartrate

For research use only

Related Research Areas

Microtubules

Citations for Vinorelbine ditartrate

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