Chemical Name: (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl ester
Biological ActivitySelective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Vinorelbine (Navelbine): A third generation vinca alkaloid.
Cancer Invest., 1997;15:475
Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic vinca alkaloids vinore. and its newer derivative vinflunine.
Ngan et al.
The effects of vinflunine, vinorelbine, and vinbla. on centromere dynamics.
Okouneva et al.
Mol.Cancer Ther., 2003;2:427
Citation for Vinorelbine ditartrate
The citations listed below are publications that use Tocris products. Selected citations for Vinorelbine ditartrate include:
1 Citation: Showing 1 - 1
Metronomic vinorelbine: Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition.
Authors: Mavroeidis Et al.
Front Cell Neurosci 2015;47:455
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