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Vinorelbine ditartrate

3401 1 Citation Datasheet / COA / SDS
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3401/50
Vinorelbine ditartrate | CAS No. 125317-39-7 | Microtubule Binding Compounds
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Description: Selective mitotic microtubule antagonist
Alternative Names: Navelbine

Chemical Name: (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl ester

Purity: ≥97%

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Citations (1)
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Biological Activity

Vinorelbine ditartrate is a selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.

Technical Data

M.Wt:
1079.1
Formula:
C45H54N4O8.2C4H6O6
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
125317-39-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Vinorelbine ditartrate

The citations listed below are publications that use Tocris products. Selected citations for Vinorelbine ditartrate include:

1 Citation: Showing 1 - 1

  1. Metronomic vinorelbine: Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition.
    Authors: Mavroeidis Et al.
    Front Cell Neurosci  2015;47:455

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