Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50
= 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50
= 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Vinorelbine (Navelbine): A third generation vinca alkaloid.
Cancer Invest., 1997;15:475
Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic vinca alkaloids vinorelbine and its newer derivative vinflunine.
Ngan et al.
The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics.
Okouneva et al.
Mol.Cancer Ther., 2003;2:427
The citations listed below are publications that use Tocris products. Selected citations for Vinorelbine ditartrate include:
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