Vinorelbine ditartrate

Catalog # Availability Size / Price Qty
3401/10
3401/50
Microtubule Binding Compounds Small Molecule
1 Image
Description: Selective mitotic microtubule antagonist
Alternative Names: Navelbine

Chemical Name: (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl ester

Purity: ≥97%

Product Details
Citations (1)
Reviews

Biological Activity

Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.

Technical Data

M.Wt:
1079.1
Formula:
C45H54N4O8.2C4H6O6
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
125317-39-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citation for Vinorelbine ditartrate

The citations listed below are publications that use Tocris products. Selected citations for Vinorelbine ditartrate include:

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