VU 0238429

Key Product Details

Product Description

VU 0238429 is a selective positive allosteric modulator of M₅ receptors (EC₅₀ values are 1.16, >30 and >30 μM at M₅, M₁ and M₃ receptors respectively). Displays no activity at M₂ and M₄ receptors.

Product Specifications for VU 0238429

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 0238429

The following data is based on the product molecular weight 351.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.85 mL	14.23 mL	28.47 mL
5 mM	0.57 mL	2.85 mL	5.69 mL
10 mM	0.28 mL	1.42 mL	2.85 mL
50 mM	0.06 mL	0.28 mL	0.57 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Bridges Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J.Med.Chem. 2009 PMID: 19438238

Product Documents for VU 0238429