Selective positive allosteric modulator of M5
values are 1.16, >30 and >30 μ
M at M5
receptors respectively). Displays no activity at M2
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All Tocris products are intended for laboratory research use only.
Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.
Bridges et al.