VU 0365114

Key Product Details

Product Description

VU 0365114 is a selective positive allosteric modulator of M₅ (EC₅₀ values are 2.7 μM for human M₅, and >30 μM for M₁, M₂, M₃ and M₄ receptors).

Product Specifications for VU 0365114

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for VU 0365114

The following data is based on the product molecular weight 397.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.52 mL	12.58 mL	25.17 mL
5 mM	0.50 mL	2.52 mL	5.03 mL
10 mM	0.25 mL	1.26 mL	2.52 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Bridges Heterobiaryl and heterobiaryl ether derived M₅ positive allosteric modulators. Bioorg.Med.Chem.Lett. 2010 PMID: 20801651
• Bridges Chemical lead optimization of a pan G_q mAChR M₁, M₃, M₅ positive allosteric modulator (PAM) lead. Part I: development of the first highly selective M₅ PAM. Bioorg.Med.Chem.Lett. 2010 PMID: 20004578

Product Documents for VU 0365114