Acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50
= 0.18 μ
M). Exhibits hypocholesterolaemic and antiatherosclerotic activity in vivo
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Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell dervied foam cells.
Miike et al.
Life Sci., 2008;82:79
N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]-(2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme A: cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice.
Nagata et al.
Bioavailable acyl-CoA: cholesterol acyltransferase inhibitor with anti-peroxidative activity: synthesis and biological activity of novel indolinyl amide and urea derivatives.
Kamiya et al.