PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC50
= 0.183 μ
M). Also competitively inhibits F-6-P (Ki
= 0.094 μ
M). Inhibits cell growth (GI50
= 2.7 μ
M) in a XTT-based in vitro
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Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect.
Seo et al.
PLoS One, 2011;6:e24179