Catalog Number: 5048
Chemical Name: Ethyl 7-hydroxy-2-oxo-2H-1-benzopyran-3-carboxylate
Biological Activity
PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor (IC50 = 0.183 μM). Also competitively inhibits F-6-P (Ki = 0.094 μM). Inhibits cell growth (GI50 = 2.7 μM) in a XTT-based in vitro toxicology assay.
Technical Data
  • M.Wt:
    234.2
  • Formula:
    C12H10O5
  • Solubility:
    Soluble to 50 mM in DMSO and to 20 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    6093-71-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Structure-based development of small molecule PFKFB3 inhibitors: a framework for potential cancer therapeutic agents targeting the Warburg effect.
    Seo et al.
    PLoS One, 2011;6:e24179

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